Likewise, Conn’s syndrome is primary hyperaldosteronism (PH), either from an aldosterone-producing adenoma or bilateral idiopathic hyperplasia. Cushing’s syndrome is a clinical condition resulting from excessive levels of circulating glucocorticoids and can be caused by adrenocortical adenomas. Though the majority are clinically silent, functional adenomas from either the cortex of medulla can lead to overproduction of any of their associated hormones.Įponymous names are associated with syndromes of adrenal cortical hyperfunction. The adrenal medulla is part of the sympathetic nervous system and produces the catecholamines epinephrine and norepinephrine (also known as adrenaline and noradrenaline).Īdrenal adenomas are benign tumors of the adrenal glands, which can be either functioning or non-functioning. The outer zone is the glomerulosa, which secretes mineralocorticoid the intermediate zone is the fasciculata, which secretes glucocorticoids, most importantly cortisol and the innermost zone is the reticularis, which secretes androgens. The adrenal cortex consists of three concentric zones. Each adrenal gland (also known as suprarenal gland) is essentially two separate and distinct endocrine glands – the cortex and the medulla.
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